Emily Carmody, MD, Assistant Professor of Orthopaedics and Assistant Professor at the Wilmot Cancer Center will lead a team of investigators through an exciting pilot project over the next year. Dr. Carmody specializes in treating both benign and malignant musculoskeletal tumors in adults and children. She has a particular interest in limb-sparing surgery and endoprosthetic reconstruction for treating bone sarcomas. Dr. Carmody also specializes in metabolic bone disorders including osteoporosis and osteopenia.
Dr. Carmody, along with Michael Zuscik, PhD (Associate Professor of Orthopaedics) and Christopher Ritchlin (Professor of Medicine) on a pilot project entitled “Assessment of Forteo as a Therapeutic to Treat Knee Osteoarthritis.” Traditional treatment strategies for Osteoarthritis are palliative, with the focus on pain management and joint replacement. Development of disease-modifying agents that can rejuvenate cartilage is a great unmet need. Thus, development of an effective treatment for Osteoarthritis is a vital public health initiative with potential for tremendous impact.
Data mined from the NIH-sponsored Osteoarthritis Initiative revealed improved WOMAC knee function scores in arthritic subjects coincidentally prescribed Forteo to treat osteoporosis. These preclinical and human data provide compelling rationale to study Forteo as a novel Osteoarthritis therapy directed at improving joint structure and function. The central Aim of this research study is to challenge the paradigm that cartilage loss in Osteoarthritis is irreversible.
Dr. Carmody received funding to complete this research project through the CTSI Investigator-initiated Pilot Studies for Faculty program. Click here to learn more about this program and how to apply for funding.